My gut says this should be a non issue, assuming of course that the piston is long enough to resist the twisting forces created by an off center load (at least 1:2 dia:length). But we are talking several hundred pounds here if I run at 200psi, and a 1.5-2" dia piston.
Here's a quick mock up of a small section of barrel/chambers:

(please don't dwell on the sizes/ratios involved here... I just picked some random pipe sizes for this illustration)